Armata Pharmaceuticals is a World Leader in Bacteriophage Science
At Armata Pharmaceuticals, we have built a challenging and dynamic work environment that values talent, initiative, collaboration and commitment.
We are seeking passionate and dedicated individuals eager to join our scientific team to develop the next-generation of antimicrobial therapies based on harnessing the power of bacteriophage through synthetic biology.
Armata Pharmaceuticals is an equal opportunity employer. We recognize the importance of a diverse employee population and encourage applicants with various backgrounds and experiences. All qualified applicants will be considered for employment and will not be discriminated against on the basis of race; color; religion; genetic information; national origin; sex; pregnancy, childbirth, or related medical conditions; familial status; age; disability; military or veteran status; or any other protected class under federal, state, or local law.
Open Positions
Scientist – Process Development
About this Position:
The Scientist will work in the Process Development group to design, develop, and optimize methods for downstream processing of bacteriophage at large scale. This role is also expected to work closely with Manufacturing group in the transfer of downstream methods to support regulatory approval processes.
Job description and technical requirements:
- Develop and implement robust and scalable strategies for improving downstream manufacturing processes for early and late stage clinical in collaboration with fellow scientists and research associates
- Execute and support process development activities and projects using technical experience, engineering principles, and equipment knowledge
- Conduct experiments and analyses as a part of variety of research and development activities such as small-scale studies, scale-up studies, technology transfer and process development following Design of Experiments
- Oversees day-to-day operations of the Process Development and Manufacturing purification labs. Maintains constant supply of materials, maintenance services etc. for the efficient function of labs
- Actively participate as a member of multi-functional project teams, executing projects from concept to practical application
- Evaluate and summarize the experimental results, develop, and test hypotheses to improve understanding of downstream purification strategies, yield, purity and recovery
- Prepare internally reviewed technical reports, CMC documents, and oral presentations
Qualifications and Experience:
- MS or PhD degree in Engineering, Biochemistry, Biotechnology or closely related discipline with minimum of 3 years industry experience in protein purification development
- Working knowledge of scale up and scale down principles for fermentation, chromatography and filtration unit operations and column packing procedures
- Hands on experience and knowledge of different types of chromatography resins
- Hands on experience with purifying proteins using equipment such as chromatography purification systems (e.g., AKTA, AZURA, BioRad, Sartorius), TFF and NFF systems (e.g., AKTA crossflow, Sartorius TFF). Experience with filtration and chromatography.
- Working knowledge of protein chemistry, protein analytics and bioprocess technology
- Experience with downstream process development specific to phage or large molecular complexes is a plus
- Experience in process equipment selection and procurement
- Fundamental understanding and/or exposure to GMP environment is desirable
- Experience and/or exposure to preparation of CMC sections of regulatory submissions is desirable
- Strong oral and written communication skills. Must be able to communicate effectively with all echelons of Management and staff
- Sound understanding of statistical experimental design and analysis, such as design of experiments, is a plus
- Ability to quickly integrate into a fast-paced team, learning new techniques and protocols as needed
- Excellent English communication and reading/writing skills
- Must be reliable, organized, detail oriented, and a self-starter with the ability to prioritize and work with minimal supervision
- Strong team-player and able to work well in small groups and independently
- Self-motivated, organized, capable of working independently, as well as in a collaborative/group environment to collaborate with manufacturing staff on experimental studies and GMP manufacturing
Working Conditions:
This is a full-time position for work in a laboratory environment. Reasonable accommodations may be made to enable individuals with disabilities to perform essential functions. There is little to no travel required of this position, with the exception of required training and possible conference or event attendance.
About Armata Pharmaceuticals, Inc.:
Armata is a clinical-stage biotechnology company focused on the development of precisely targeted bacteriophage therapeutics for the treatment of antibiotic-resistant and difficult-to-treat bacterial infections using its proprietary bacteriophage-based technology. Armata is developing and advancing a broad pipeline of natural and synthetic phage candidates, including clinical candidates for Pseudomonas aeruginosa, Staphylococcus aureus, and other pathogens. In addition, in collaboration with Merck, known as MSD outside of the United States and Canada, Armata is developing proprietary synthetic phage candidates to target an undisclosed infectious disease agent. Armata is committed to advancing phage with drug development expertise that spans bench to clinic including in-house phage specific GMP manufacturing.
Send cover letter and CV to: careers@armatapharma.com
Manufacturing Associate
About this Position:
The Manufacturing Associate will work within a manufacturing team to produce pharmaceutical products in a clean room environment following Good Manufacturing Practices (GMP).
Job description and technical requirements:
- Initiate, setup, and operate production equipment to manufacture pharmaceutical products. Production equipment utilized includes, but is not limited to:
- Fermenters
- Pumps and filters
- Centrifuges
- Tangential flow filtration systems
- FPLC systems
- Small volume liquid fillers
- Plan, initiate, setup, and manufacture bulk quantities of pharmaceutical products in a controlled environment according to production batch records within current Good Manufacturing Practices (cGMP)
- Coordinate with Formulation Group on scale-up and transfer of manufacturing processes
- Review and maintain log books, production records, and associate documents to comply with regulatory requirements, cGMPs, and Standard Operating Procedures (SOP).
- Clean and sample processing equipment and manufacturing areas according to SOPs.
- Other duties as assigned.
Qualifications and Experience:
- Bachelor’s degree, preferably in a science or engineering field.
- In lieu of a bachelor’s degree, will consider a minimum of three (3) years closely related experience in a GMP or clean room assembly environment with an Associate Degree or six (6) years closely related experience in a GMP or clean room assembly environment with a High School Diploma or equivalent.
- Demonstrated ability to be organized and work independently and in small work groups.
- Must be able to assist in trouble shooting activities and repairs to production equipment.
- Demonstrated mathematical skills, including the ability to perform addition, subtraction, multiplication, division, and conversions.
- Detail oriented. Demonstrated ability to read, comprehend, and follow written instructions.
- Demonstrated written and verbal communication skills are required.
- Experience in a related GMP environment within biotechnology/pharmaceutical industry strongly preferred.
- Must be able to learn and perform basic computer operations such as MS Office and Outlook and other computer-based software
Working Conditions:
This is a full-time position for work in a laboratory environment. Reasonable accommodations may be made to enable individuals with disabilities to perform essential functions. There is little to no travel required of this position, with the exception of required training and possible conference or event attendance.
About Armata Pharmaceuticals, Inc.:
Armata is a clinical-stage biotechnology company focused on the development of precisely targeted bacteriophage therapeutics for the treatment of antibiotic-resistant and difficult-to-treat bacterial infections using its proprietary bacteriophage-based technology. Armata is developing and advancing a broad pipeline of natural and synthetic phage candidates, including clinical candidates for Pseudomonas aeruginosa, Staphylococcus aureus, and other pathogens. In addition, in collaboration with Merck, known as MSD outside of the United States and Canada, Armata is developing proprietary synthetic phage candidates to target an undisclosed infectious disease agent. Armata is committed to advancing phage with drug development expertise that spans bench to clinic including in-house phage specific GMP manufacturing.
Send cover letter and CV to: careers@armatapharma.com
Research Associate – Formulation
About this Position:
The Research Associate I position will report to the Senior Scientist. The RA will assist with completing individual formulation development projects in support of Armata’s bacteriophage pipeline programs. Duties will include assembly of study designs, performance of laboratory experiments, organization of data and laboratory notebooks, and analysis of study results.
Job description and technical requirements:
- Skillful, independent individual who has entry level experience in drug substance, drug product characterization and formulation
- Assist in liquid, spray dry and lyophilized bacteriophage formulation development activities to support preclinical and clinical drug product development
- Execute studies including pre-formulation characterization and stability studies
- Familiar with analytical techniques to study long and short-term stability of biologics
- Familiar with concepts used for delivery and stabilization of biological drugs
- Comfortable with operating mechanical equipment like spray dryer, lyophilizer
- Develop and optimize new assays as needed
- Designs protocols and procedures with supervisor
- Process, analyze and organize large data sets
- Perform cross-functional tasks to support product development
- Assist in general upkeep of laboratory and maintain a clean and organized work environment
- Maintain laboratory notebook and accurate records of daily experiments
- Understand and comply with company standard operating procedures and safety procedures
- Read and understand scientific language, literature and publications as necessary
- Other duties as assigned
Qualifications and Experience:
- A Bachelor’s or master’s degree in Pharmaceutics/Industrial Pharmacy, Bioengineering, Chemical Engineering, Biochemistry or related scientific field with prior laboratory experience in a lab or research setting in the area of drug formulation and/or delivery development and characterization
- Knowledge and/or experience with lyophilized and spray-dried dosage form, complex biological assemblies and/or understanding of microbiological concepts and approaches is a plus
- Experience working with bacteria and bacteriophages with excellent aseptic techniques
- Understanding of statistics and statistical software to interpret experimental results
- Excellent English communication and reading/writing skills
- Must be reliable, organized, detail oriented, and a self-starter with the ability to prioritize and work with minimal supervision
- Strong team-player and able to work well in small groups and independently
Working Conditions:
This is a full-time position for work in a laboratory environment. Reasonable accommodations may be made to enable individuals with disabilities to perform essential functions. There is little to no travel required of this position, apart from required training and possible conference or event attendance.
About Armata Pharmaceuticals, Inc.:
Armata is a clinical-stage biotechnology company focused on the development of precisely targeted bacteriophage therapeutics for the treatment of antibiotic-resistant and difficult-to-treat bacterial infections using its proprietary bacteriophage-based technology. Armata is developing and advancing a broad pipeline of natural and synthetic phage candidates, including clinical candidates for Pseudomonas aeruginosa, Staphylococcus aureus, and other pathogens. In addition, in collaboration with Merck, known as MSD outside of the United States and Canada, Armata is developing proprietary synthetic phage candidates to target an undisclosed infectious disease agent. Armata is committed to advancing phage with drug development expertise that spans bench to clinic including in-house phage specific GMP manufacturing.
Send cover letter and CV to: careers@armatapharma.com
Assoc. Scientist/Scientist Phage & Bacterial Genetics, Engineering & Synthetic Biology
About this Position:
This position will evaluate existing engineering methods and devise new ones in order to build improved phages as needed per the goals of our clinical development programs. The work will involve genetically altering phages and their hosts to improve their safety, efficacy or manufacturability profiles, using expertise in engineering prokaryotic organisms and/or phages through traditional and modern molecular and genetic techniques. This role is also expected to participate in the development, testing and validation of assays required for the transition of drug candidates to manufacturing and in support of regulatory approval processes.
Technical Requirements:
- Must be comfortable handling a variety of BSL2 pathogenic bacteria safely
- Must have working knowledge of bacterial and phage genetics (gene function analysis, directed and undirected mutagenesis and evolution, mutant library construction, transposon mutagenesis, etc.).
- Must be proficient in one or more cloning technique(s) (isothermal assembly, restriction/ligation, quickchange®, allele exchange through suicide plasmids, recombineering in bacteria and yeast, etc.)
- Must have working knowledge of DNA extraction, amplification and analysis methods (PCR, restriction digestion, gel electrophoresis, etc.)
- Experience with the genetic manipulation of bacteriophages is highly desirable
- Experience with high throughput screening is highly desirable
- Experience with synthetic biology in prokaryotic organisms is a plus
- Experience with in vitro transcription/translation systems is a plus
- Experience with generating and analyzing Next Generation Sequencing data and/or comparative genomics is a plus
- Maintain a laboratory notebook and accurate records of daily experiments
- Understand and comply with the company’s standard operating procedures and safety procedures
- Read and understand scientific language, literature and other publications as necessary
- Assist in general upkeep of laboratory and maintain a clean and organized work environment
- Other duties as assigned
Qualifications and Experience:
- Master’s degree and > 5 years of extremely relevant experience or a PhD degree in the fields of bacterial genetics, genetic engineering and/or synthetic biology of prokaryotes (or extremely relevant experience in these fields).
- Applicants should be able to work independently, follow existing protocols and develop new ones where appropriate, and contribute to the general scientific and technological development of the company
- Relevant experience includes but is no limited to prokaryotic microbiology (isolating, growing and storing BSL1-2 bacteria and their mobile genetic elements), molecular cloning and genetics/genetic engineering (plasmid cloning, genome engineering), high throughput functional screening and synthetic biology (synthetic genetic regulation, function transfer between organisms, etc.) and proficiency in comparative genomics.
- Must have prior experience in a laboratory or research setting
- Ability to quickly integrate into a fast-paced team, learning new techniques and protocols as needed
- Excellent English communication and reading/writing skills
- Must be reliable, organized, detail oriented, and a self-starter with the ability to prioritize and work with minimal supervision
- Strong team-player and able to work well in small groups and independently
Working Conditions:
This is a full-time position for work in a laboratory environment. Reasonable accommodations may be made to enable individuals with disabilities to perform essential functions. There is little to no travel required of this position, with the exception of required training and possible conference or event attendance.
About Armata Pharmaceuticals, Inc:
Armata is a clinical-stage biotechnology company focused on the development of precisely targeted bacteriophage therapeutics for the treatment of antibiotic-resistant and difficult-to-treat bacterial infections using its proprietary bacteriophage-based technology. Armata is developing and advancing a broad pipeline of natural and synthetic phage candidates, including clinical candidates for Pseudomonas aeruginosa, Staphylococcus aureus, and other pathogens. In addition, in collaboration with Merck, known as MSD outside of the United States and Canada, Armata is developing proprietary synthetic phage candidates to target an undisclosed infectious disease agent. Armata is committed to advancing phage with drug development expertise that spans bench to clinic including in-house phage specific GMP manufacturing.
Send cover letter and CV to: careers@armatapharma.com
Research Associate I DNA Sequencing and Genetic Engineering
Armata Pharmaceuticals is a clinical-stage biotechnology company advancing the development of precisely targeted bacteriophage therapeutics for the treatment of drug-resistant bacterial infections.
Position Objective:
The Research Associate I position will be integrated to the discovery and biological engineering team and assist with efforts to identify new bacteriophages, characterize their microbiological and genomic features and help develop engineering pipelines. Opportunities exist to expand into other sectors of the development pipeline.
Responsibilities:
- Grow and maintain bacterial cultures and bacteriophage stocks
- Extract and purify DNA from bacteriophages, plasmids and bacteria
- Perform plasmid, phage and bacterial genome sequencing as needed (Sanger, Illumina and/or minion technologies)
- Assist in the cloning of plasmids, engineering of bacteria and phages as needed
- Contribute to screening efforts for the isolation and characterization of new bacteriophages
- Maintain laboratory notebook and accurate records of daily experiments
- Understand and comply with company standard operating procedures and safety procedures
- Read and understand scientific language, literature and publications as necessary
- Assist in general upkeep of laboratory and maintain a clean and organized work environment
- Other duties as assigned
Minimum & Preferred Qualifications:
- Must have a Bachelor’s or Master’s Degree in Microbiology, Cell Biology, genetic engineering, synthetic biology or related field with experience in microbiology
- Must have prior laboratory experience in a lab or research setting
- Must have Experience with DNA sequencing (Sanger sequencing and/or next generation sequencing)
- Must be proficient in aseptic techniques and general microbiological techniques (streaking, plating, storing micro-organisms)
- Experience with genetic engineering highly desirable (plasmid cloning, bacterial genome engineering and/or bacteriophage modification).
- Ability to quickly integrate into a fast-paced team, learning new techniques and protocols as needed
- Excellent English communication and reading/writing skills
- Must be reliable, organized, detail oriented, and a self-starter with the ability to prioritize and work with minimal supervision
- Strong team-player and able to work well in small groups and independently
- Familiarity with bacteriophages a plus but not required
Working Conditions:
This is a full-time position for work in a laboratory environment. Reasonable accommodations may be made to enable individuals with disabilities to perform essential functions. There is little to no travel required for this position with the exception of required training and possible conference or event attendance.
Employment Compensation:
Position is eligible for performance bonus. Pay is competitive and commensurate with skill set and experience. Benefits include medical, dental, vision and life insurance, vacation plan, and 401(k). Consideration for future stock option grants may be available.
Application Process:
Send cover letter and CV to: careers@armatapharma.com