Assoc. Scientist/Scientist Phage & Bacterial Genetics, Engineering & Synthetic Biology
About this Position:
This position will evaluate existing engineering methods and devise new ones in order to build improved phages as needed per the goals of our clinical development programs. The work will involve genetically altering phages and their hosts to improve their safety, efficacy or manufacturability profiles, using expertise in engineering prokaryotic organisms and/or phages through traditional and modern molecular and genetic techniques. This role is also expected to participate in the development, testing and validation of assays required for the transition of drug candidates to manufacturing and in support of regulatory approval processes.
- Must be comfortable handling a variety of BSL2 pathogenic bacteria safely
- Must have working knowledge of bacterial and phage genetics (gene function analysis, directed and undirected mutagenesis and evolution, mutant library construction, transposon mutagenesis, etc.).
- Must be proficient in one or more cloning technique(s) (isothermal assembly, restriction/ligation, quickchange®, allele exchange through suicide plasmids, recombineering in bacteria and yeast, etc.)
- Must have working knowledge of DNA extraction, amplification and analysis methods (PCR, restriction digestion, gel electrophoresis, etc.)
- Experience with the genetic manipulation of bacteriophages is highly desirable
- Experience with high throughput screening is highly desirable
- Experience with synthetic biology in prokaryotic organisms is a plus
- Experience with in vitro transcription/translation systems is a plus
- Experience with generating and analyzing Next Generation Sequencing data and/or comparative genomics is a plus
- Maintain a laboratory notebook and accurate records of daily experiments
- Understand and comply with the company’s standard operating procedures and safety procedures
- Read and understand scientific language, literature and other publications as necessary
- Assist in general upkeep of laboratory and maintain a clean and organized work environment
- Other duties as assigned
Qualifications and Experience:
- Master’s degree and > 5 years of extremely relevant experience or a PhD degree in the fields of bacterial genetics, genetic engineering and/or synthetic biology of prokaryotes (or extremely relevant experience in these fields).
- Applicants should be able to work independently, follow existing protocols and develop new ones where appropriate, and contribute to the general scientific and technological development of the company
- Relevant experience includes but is no limited to prokaryotic microbiology (isolating, growing and storing BSL1-2 bacteria and their mobile genetic elements), molecular cloning and genetics/genetic engineering (plasmid cloning, genome engineering), high throughput functional screening and synthetic biology (synthetic genetic regulation, function transfer between organisms, etc.) and proficiency in comparative genomics.
- Must have prior experience in a laboratory or research setting
- Ability to quickly integrate into a fast-paced team, learning new techniques and protocols as needed
- Excellent English communication and reading/writing skills
- Must be reliable, organized, detail oriented, and a self-starter with the ability to prioritize and work with minimal supervision
- Strong team-player and able to work well in small groups and independently
This is a full-time position for work in a laboratory environment. Reasonable accommodations may be made to enable individuals with disabilities to perform essential functions. There is little to no travel required of this position, with the exception of required training and possible conference or event attendance.
About Armata Pharmaceuticals, Inc:
Armata is a clinical-stage biotechnology company focused on the development of precisely targeted bacteriophage therapeutics for the treatment of antibiotic-resistant and difficult-to-treat bacterial infections using its proprietary bacteriophage-based technology. Armata is developing and advancing a broad pipeline of natural and synthetic phage candidates, including clinical candidates for Pseudomonas aeruginosa, Staphylococcus aureus, and other pathogens. In addition, in collaboration with Merck, known as MSD outside of the United States and Canada, Armata is developing proprietary synthetic phage candidates to target an undisclosed infectious disease agent. Armata is committed to advancing phage with drug development expertise that spans bench to clinic including in-house phage specific GMP manufacturing.
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